Perindopril
Perindopril is an active ingredient of the class «ACE inhibitor».
Long-acting ACE inhibitor used to treat high blood pressure, heart failure, or stable coronary artery disease
Boxed warning (US label)
Fetal toxicity. When pregnancy is detected, discontinue perindopril erbumine as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
What it is used for
- Congestive heart failure
- Arterial hypertension
- Coronary artery disease
- Cardiovascular disease
- Myocardial infarction
Perindopril erbumine tablets are indicated for the treatment of patients with essential hypertension.
How it works
- Angiotensin-converting enzyme inhibitor
Class: ACE inhibitor
Common side effects
Hypertension: Most common adverse events (incidence greater than or equal to 5%) are cough, dizziness and back pain. Stable Coronary Artery Disease: Most common adverse events leading to discontinuation were cough, drug intolerance, and hypotension.
Who should not take it
Perindopril erbumine tablets are contraindicated in patients known to be hypersensitive (including angioedema) to this product or to any other ACE inhibitor.
Pregnancy and breastfeeding
Category D. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death.
Milk of lactating rats contained radioactivity following administration of 14 C-perindopril. It is not known whether perindopril is secreted in human milk.
Interactions
- Amiloride — hyperkalemia
- Bromocriptine — hyperinsulinism, hypotension
- Celecoxib — increased systemic arterial blood pressure, kidney failure, hyperkalemia
- Ciclosporin — hyperkalemia, kidney failure
- Diclofenac — kidney failure, increased systemic arterial blood pressure, hyperkalemia
- Furosemide — orthostatic hypotension, hypotension
- Hydrochlorothiazide — decreased blood pressure, hypotension
- Ibuprofen — kidney failure, increased systemic arterial blood pressure, hyperkalemia
- Indapamide — decreased blood pressure, hypotension
- Indometacin — increased systemic arterial blood pressure, kidney failure, hyperkalemia
- Irbesartan — kidney failure, hyperkalemia, hypotension, acute kidney injury, syncope
- Ketoprofen — kidney failure, hyperkalemia, increased systemic arterial blood pressure
- Losartan — syncope, hypotension, kidney failure, hyperkalemia, acute kidney injury
- Meloxicam — hyperkalemia, increased systemic arterial blood pressure, kidney failure
- Naproxen — hyperkalemia, increased systemic arterial blood pressure, kidney failure
- Piroxicam — kidney failure, hyperkalemia, increased systemic arterial blood pressure
- Spironolactone — hypotension, hyperkalemia
- Telmisartan — hyperkalemia, syncope, acute kidney injury, kidney failure, hypotension
- Trimethoprim — hyperkalemia
- Valsartan — syncope, acute kidney injury, hyperkalemia, hypotension, kidney failure
- Lithium carbonate
- Sirolimus
Brand names
United States
Aceon
Canada
Ag-Perindopril Erbumine · Alta-Perindopril · Apo-Perindopril · Apo-Perindopril Arginine · Auro-Perindopril · Bio-Perindopril · Jamp Perindopril Erbumine · M-Perindopril Erbumine · Mar-Perindopril · Mint-Perindopril · Nb-Perindopril · Nra-Perindopril · Pms-Perindopril · Riva-Perindopril · Sandoz Perindopril Erbumine · Teva-Perindopril
Approval status
- US Food and Drug Administration
- prescription · since 1993
- Health Canada
- prescription · marketed
- First approval anywhere
- 1993
Codes
- ATC
- C09AA04
- RxNorm CUI
- 54552
- ChEMBL
- CHEMBL1581
- PubChem CID
- 40466996
- UNII
- Y5GMK36KGY
- Wikidata
- Q277785
Frequently asked questions
What is Perindopril used for?
Perindopril is used for: Congestive heart failure, Arterial hypertension, Coronary artery disease, Cardiovascular disease, and Myocardial infarction.
What kind of medicine is Perindopril?
Perindopril is an active ingredient of the class «ACE inhibitor».
What are the brand names of Perindopril?
Brand names of Perindopril include Aceon, Ag-Perindopril Erbumine, Alta-Perindopril, Apo-Perindopril, Apo-Perindopril Arginine, Auro-Perindopril, Bio-Perindopril, and Jamp Perindopril Erbumine.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- Health Canada Drug Product Database (Open Government Licence – Canada)