Indapamide
Indapamide is an active ingredient of the class «diuretic».
Chemical compound
What it is used for
- Nephrotic syndrome
- Anasarka
- Arterial hypertension
- Congestive heart failure
- Cardiovascular disease
- Heart failure
- Toxemia
Indapamide tablets are indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs. Indapamide tablets are also indicated for the treatment of salt and fluid retention associated with congestive heart failure.
How it works
- Thiazide-sensitive sodium-chloride cotransporter inhibitor
Class: diuretic
Common side effects
Most adverse effects have been mild and transient. The Clinical Adverse Reactions listed in Table 1 represent data from Phase II/III placebo-controlled studies (306 patients given indapamide 1.25 mg).
Who should not take it
Known hypersensitivity to indapamide or to other sulfonamide-derived drugs.
Pregnancy and breastfeeding
: Teratogenic Effects: Reproduction studies have been performed in rats, mice and rabbits at doses up to 6,250 times the therapeutic human dose and have revealed no evidence of impaired fertility or harm to the fetus due to indapamide.
: It is not known whether this drug is excreted in human milk. Because most drugs are excreted in human milk, if use of this drug is deemed essential, the patient should stop nursing.
Interactions
- Arsenic trioxide — torsades de pointes, long QT syndrome, Achor-Smith syndrom
- Aspirin — acute kidney injury, nephrotoxicity
- Bromocriptine — hyperglycemia, increased insulin requirement, hypotension
- Captopril — decreased blood pressure, hypotension
- Celecoxib — acute kidney injury, hyponatremia, nephrotoxicity
- Desmopressin — hyponatremia
- Diclofenac — acute kidney injury, nephrotoxicity, hyponatremia
- Digoxin — toxicity, vomiting, heart arrhythmia, nausea
- Enalapril — hypotension, decreased blood pressure
- Ibuprofen — acute kidney injury, hyponatremia, nephrotoxicity
- Indometacin — hyponatremia, nephrotoxicity, acute kidney injury
- Ketoprofen — hyponatremia, acute kidney injury, nephrotoxicity
- Meloxicam — nephrotoxicity, hyponatremia, acute kidney injury
- Naproxen — acute kidney injury, nephrotoxicity, hyponatremia
- Perindopril — decreased blood pressure, hypotension
- Piroxicam — nephrotoxicity, hyponatremia, acute kidney injury
- Quinapril — hypotension, decreased blood pressure
- Ramipril — hypotension, decreased blood pressure
- Sotalol — torsades de pointes, cardiotoxicity, Achor-Smith syndrom, hypotension, long QT syndrome, pulseless electrical activity
- Lithium carbonate
Brand names
Canada
Apo-Indapamide · Jamp Indapamide · Mylan-Indapamide
Other trade names
Cardide sr · Ethibide xl · Indaxa 2.5 · Indipam xl · Mapemid xl · Natrilix · Natrilix sr · Nindaxa 2.5 · Opumide 2.5 · Rawel xl · Tensaid xl · Varbim xl
Approval status
- US Food and Drug Administration
- prescription · since 1983
- Health Canada
- prescription · marketed
- First approval anywhere
- 1983
Codes
- ATC
- C03BA11
- RxNorm CUI
- 5764
- ChEMBL
- CHEMBL406
- PubChem CID
- 3702
- UNII
- F089I0511L
- Wikidata
- Q1078392
Frequently asked questions
What is Indapamide used for?
Indapamide is used for: Nephrotic syndrome, Anasarka, Arterial hypertension, Congestive heart failure, Cardiovascular disease, Heart failure, and Toxemia.
What kind of medicine is Indapamide?
Indapamide is an active ingredient of the class «diuretic».
What are the brand names of Indapamide?
Brand names of Indapamide include Apo-Indapamide, Jamp Indapamide, Mylan-Indapamide, Cardide sr, Ethibide xl, Indaxa 2.5, Indipam xl, and Mapemid xl.
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- Health Canada Drug Product Database (Open Government Licence – Canada)