Treosulfan
Treosulfan is an active ingredient of the class «alkyl sulfonate».
Chemical compound
Boxed warning (US label)
Myelosuppression. MYELOSUPPRESSION GRAFAPEX causes severe and prolonged myelosuppression at the recommended dosage. Hematopoietic stem cell transplantation is required to prevent potentially fatal complications of the prolonged myelosuppression.
What it is used for
- Neoplasm
- Hematopoietic stem cell transplantation
GRAFAPEX is an alkylating drug indicated for: Use in combination with fludarabine as a preparative regimen for allogeneic hematopoietic stem cell transplantation (alloHSCT) in adult and pediatric patients 1 year of age and older with acute myeloid leukemia (AML).. Use in combination with…
Treosulfan in combination with fludarabine is indicated as part of conditioning treatment prior to allogeneic haematopoietic stem cell transplantation (alloHSCT) in adult patients and in paediatric patients older than one month with malignant and non-malignant diseases.
How it works
- DNA cross-linking agent
Class: alkyl sulfonate
Common side effects
The following clinically significant adverse reactions are described elsewhere in the labeling: Myelosuppression Seizures Skin Disorders Injection Site Reactions and Tissue Necrosis Secondary Malignancies The most common adverse reactions (≥20%) are musculoskeletal pain, stomatitis, pyrexia, nausea, edema, infection…
Who should not take it
GRAFAPEX is contraindicated in patients with hypersensitivity to any component of the drug product. Hypersensitivity to any component of the drug product.
Brand names
United States
Grafapex
European Union
Trecondi
Canada
Trecondyv
Other trade names
Graftrevo · Kepcondi · Ovastat · Treograft
Approval status
- US Food and Drug Administration
- prescription · since 2025
- European Medicines Agency
- authorised · since 2019
- Health Canada
- prescription · marketed
- First approval anywhere
- 2019
Codes
- ATC
- L01AB02
- RxNorm CUI
- 38508
- ChEMBL
- CHEMBL455186
- PubChem CID
- 9882105
- UNII
- CO61ER3EPI
- Wikidata
- Q7838652
Frequently asked questions
What is Treosulfan used for?
Treosulfan is used for: Neoplasm and Hematopoietic stem cell transplantation.
What kind of medicine is Treosulfan?
Treosulfan is an active ingredient of the class «alkyl sulfonate».
What are the brand names of Treosulfan?
Brand names of Treosulfan include Grafapex, Trecondi, Trecondyv, Graftrevo, Kepcondi, Ovastat, and Treograft.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)
- Health Canada Drug Product Database (Open Government Licence – Canada)