Busulfan
Busulfan is an active ingredient of the class «alkyl sulfonate».
Chemical compound
Boxed warning (US label)
WARNING MYLERAN is a potent drug. It should not be used unless a diagnosis of chronic myelogenous leukemia has been adequately established and the responsible physician is knowledgeable in assessing response to chemotherapy.
What it is used for
- Myelofibrosis
- Acute myeloid leukemia
- B-cell lymphoma
- Chronic myeloid leukemia
- Polycythemia vera
- Leukemia
- Neoplasm
- Hematopoietic stem cell transplantation
MYLERAN (busulfan) is indicated for the palliative treatment of chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia.
Busulfan Fresenius Kabi followed by cyclophosphamide (BuCy2) is indicated as conditioning treatment prior to conventional haematopoietic progenitor cell transplantation (HPCT) in adult patients when the combination is considered the best available option.
How it works
- DNA inhibitor
Class: alkyl sulfonate
Common side effects
Hematological Effects The most frequent, serious, toxic effect of busulfan is dose-related myelosuppression resulting in leukopenia, thrombocytopenia, and anemia. Myelosuppression is most frequently the result of a failure to discontinue dosage in the face of an undetected decrease in leukocyte or platelet counts.
Who should not take it
MYLERAN is contraindicated in patients in whom a definitive diagnosis of chronic myelogenous leukemia has not been firmly established.
Pregnancy and breastfeeding
Busulfan may cause fetal harm when administered to a pregnant woman.
It is not known whether this drug is excreted in human milk.
Interactions
Brand names
United States
Busulfex · Myleran
European Union
Busulfan Fresenius Kabi
Canada
Myleran · Pms-Busulfan
Other trade names
Busilvex
Approval status
- US Food and Drug Administration
- prescription · since 1954
- European Medicines Agency
- authorised · since 2014
- Health Canada
- prescription · marketed
- First approval anywhere
- 1954
Codes
- ATC
- L01AB01
- RxNorm CUI
- 1828
- ChEMBL
- CHEMBL820
- PubChem CID
- 2478
- UNII
- G1LN9045DK
- Wikidata
- Q348922
Frequently asked questions
What is Busulfan used for?
Busulfan is used for: Myelofibrosis, Acute myeloid leukemia, B-cell lymphoma, Chronic myeloid leukemia, Polycythemia vera, Leukemia, Neoplasm, and Hematopoietic stem cell transplantation.
What kind of medicine is Busulfan?
Busulfan is an active ingredient of the class «alkyl sulfonate».
What are the brand names of Busulfan?
Brand names of Busulfan include Busulfex, Myleran, Busulfan Fresenius Kabi, Pms-Busulfan, and Busilvex.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)
- Health Canada Drug Product Database (Open Government Licence – Canada)