Prazosin
Prazosin is an approved active ingredient.
Antihypertensive medication
What it is used for
- Prostatic hypertrophy
- Arterial hypertension
- Post-traumatic stress disorder
- Raynaud disease
- Urinary retention
- Diabetes
Prazosin hydrochloride capsules are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.
How it works
- Adrenergic receptor alpha-1 antagonist
Common side effects
During these trials and subsequent marketing experience, the most frequent reactions associated with prazosin hydrochloride therapy are: dizziness 10.3%, headache 7.8%, drowsiness 7.6%, lack of energy 6.9%, weakness 6.5%, palpitations 5.3%, and nausea 4.9%.
Who should not take it
Prazosin hydrochloride capsules are contraindicated in patients with known sensitivity to quinazolines, prazosin, or any of the inert ingredients.
Pregnancy and breastfeeding
Usage in Pregnancy Prazosin hydrochloride has been shown to be associated with decreased litter size at birth, 1, 4, and 21 days of age in rats when given doses more than 225 times the usual maximum recommended human dose.
Prazosin hydrochloride has been shown to be excreted in small amounts in human milk. Caution should be exercised when prazosin hydrochloride is administered to a nursing woman.
Interactions
- Atenolol — hypotension
- Bisoprolol — hypotension
- Carvedilol — hypotension
- Labetalol — hypotension
- Metoprolol — hypotension
- Nebivolol — hypotension
- Propranolol — hypotension
- Sildenafil — hypotension
- Sotalol — hypotension
- Tadalafil — hypotension
- Vardenafil — hypotension
- Verapamil — hypotension
- Midodrine
- Nicotine
Brand names
United States
Minipress · Minipress XL
Canada
Apo-Prazo · Teva-Prazosin
Other trade names
Alphavase 0.5 · Alphavase 1 · Alphavase 2 · Alphavase 5 · Hypovase · Hypovase b.d. · Kentovace
Approval status
- US Food and Drug Administration
- prescription · since 1976
- Health Canada
- prescription · marketed
- First approval anywhere
- 1976
Codes
- ATC
- C02CA01
- RxNorm CUI
- 8629
- ChEMBL
- CHEMBL2
- PubChem CID
- 4893
- UNII
- XM03YJ541D
- Wikidata
- Q425296
Frequently asked questions
What is Prazosin used for?
Prazosin is used for: Prostatic hypertrophy, Arterial hypertension, Post-traumatic stress disorder, Raynaud disease, Urinary retention, and Diabetes.
What are the brand names of Prazosin?
Brand names of Prazosin include Minipress, Minipress XL, Apo-Prazo, Teva-Prazosin, Alphavase 0.5, Alphavase 1, Alphavase 2, and Alphavase 5.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- Health Canada Drug Product Database (Open Government Licence – Canada)