Midodrine
Midodrine is an active ingredient of the class «butyroxan».
Peripheral alpha-1 agonist used for the treatment of dysautonomia and orthostatic hypotension
Boxed warning (US label)
Because midodrine hydrochloride can cause marked elevation of supine blood pressure, it should be used in patients whose lives are considerably impaired despite standard clinical care.
What it is used for
- Urinary incontinence
- Orthostatic hypotension
- Cardiovascular disease
Midodrine hydrochloride is indicated for the treatment of symptomatic orthostatic hypotension (OH).
How it works
- Adrenergic receptor alpha-1 agonist
Class: butyroxan
Common side effects
The most frequent adverse reactions seen in controlled trials were supine and sitting hypertension; paresthesia and pruritus, mainly of the scalp; goosebumps; chills; urinary urge; urinary retention and urinary frequency.
Who should not take it
Midodrine hydrochloride is contraindicated in patients with severe organic heart disease, acute renal disease, urinary retention, pheochromocytoma or thyrotoxicosis.
Pregnancy and breastfeeding
: Pregnancy Category C. Midodrine hydrochloride increased the rate of embryo resorption, reduced fetal body weight in rats and rabbits, and decreased fetal survival in rabbits when given in doses 13 (rat) and 7 (rabbit) times the maximum human dose based on…
: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when midodrine hydrochloride is administered to a nursing woman.
Interactions
Brand names
United States
Proamatine
Canada
Apo-Midodrine · Jamp Midodrine · M-Midodrine · Mar-Midodrine
Other trade names
Bramox · Gutron · Midon · Orvaten · Pro-amatine
Approval status
- US Food and Drug Administration
- prescription · since 1996
- Health Canada
- prescription · marketed
- First approval anywhere
- 1996
Codes
- ATC
- C01CA17
- RxNorm CUI
- 6963
- ChEMBL
- CHEMBL1201212
- PubChem CID
- 4195
- UNII
- 6YE7PBM15H
- Wikidata
- Q415051
Frequently asked questions
What is Midodrine used for?
Midodrine is used for: Urinary incontinence, Orthostatic hypotension, and Cardiovascular disease.
What kind of medicine is Midodrine?
Midodrine is an active ingredient of the class «butyroxan».
What are the brand names of Midodrine?
Brand names of Midodrine include Proamatine, Apo-Midodrine, Jamp Midodrine, M-Midodrine, Mar-Midodrine, Bramox, Gutron, and Midon.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- Health Canada Drug Product Database (Open Government Licence – Canada)