Fampridine
Fampridine is an approved active ingredient.
Chemical compound
What it is used for
- Multiple sclerosis
- Zenker's paralysis
- Secondary progressive multiple sclerosis
- Relapsing-remitting multiple sclerosis
- Primary progressive multiple sclerosis
AMPYRA is indicated as a treatment to improve walking in adult patients with multiple sclerosis (MS). This was demonstrated by an increase in walking speed. AMPYRA ® (dalfampridine) is a potassium channel blocker indicated to improve walking in adult patients with multiple sclerosis (MS).
Fampyra is indicated for the improvement of walking in adult patients with multiple sclerosis with walking disability (Expanded Disability Status Scale 4-7).
How it works
- Voltage-gated potassium channel blocker
Common side effects
The following serious adverse reactions are described in more detail elsewhere in the labeling: Seizures Anaphylaxis The most common adverse events (incidence ≥2% and at a rate greater than the placebo rate) for AMPYRA were urinary tract infection, insomnia, dizziness, headache, nausea, asthenia, back pain, balance…
Who should not take it
The use of AMPYRA is contraindicated in the following conditions: History of seizure Moderate or severe renal impairment (CrCl≤50 mL/min) History of hypersensitivity to AMPYRA or 4-aminopyridine; reactions have included anaphylaxis History of seizure…
Pregnancy and breastfeeding
There are no adequate data on the developmental risk associated with use of AMPYRA in pregnant women. Administration of dalfampridine to animals during pregnancy and lactation resulted in decreased offspring viability and growth at clinically relevant doses.
Interactions
Brand names
United States
Ampyra
European Union
Fampridine Accord · Fampyra
Canada
Apo-Fampridine · Auro-Fampridine · Fampyra · Pms-Fampridine · Taro-Fampridine
Other trade names
Ampyra extended release
Approval status
- US Food and Drug Administration
- prescription · since 2010
- European Medicines Agency
- authorised · since 2011
- Health Canada
- prescription · marketed
- First approval anywhere
- 2010
Codes
- ATC
- N07XX07
- RxNorm CUI
- 897018
- ChEMBL
- CHEMBL284348
- PubChem CID
- 1727
- UNII
- BH3B64OKL9
- Wikidata
- Q372539
Frequently asked questions
What is Fampridine used for?
Fampridine is used for: Multiple sclerosis, Zenker's paralysis, Secondary progressive multiple sclerosis, Relapsing-remitting multiple sclerosis, and Primary progressive multiple sclerosis.
What are the brand names of Fampridine?
Brand names of Fampridine include Ampyra, Fampridine Accord, Fampyra, Apo-Fampridine, Auro-Fampridine, Pms-Fampridine, Taro-Fampridine, and Ampyra extended release.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)
- Health Canada Drug Product Database (Open Government Licence – Canada)