Trientine
Trientine is an approved active ingredient.
Chemical compound
What it is used for
- Wilson disease
- Rheumatoid arthritis
- Primary biliary cholangitis
CUVRIOR is indicated for the treatment of adult patients with stable Wilson's disease who are de-coppered and tolerant to penicillamine. CUVRIOR is a copper chelator indicated for the treatment of adult patients with stable Wilson's disease who are de-coppered and tolerant to penicillamine.
Cuprior is indicated for the treatment of Wilson's disease in adults, adolescents and children ≥ 5 years intolerant to D-penicillamine therapy.
How it works
- Copper chelating agent
Common side effects
The following clinically significant adverse reactions are described elsewhere in the labeling: Potential for Worsening of Clinical Symptoms at Initiation of Therapy Copper Deficiency Iron Deficiency Hypersensitivity Reactions Most common adverse reactions (>5%) are abdominal pain, change of bowel habits, rash…
Who should not take it
CUVRIOR is contraindicated in patients with hypersensitivity to trientine or to any of the excipients in CUVRIOR. Hypersensitivity to trientine or to any of the excipients in CUVRIOR.
Pregnancy and breastfeeding
Available data from published literature and postmarketing experience over several decades with use of trientine for the treatment of Wilson's disease have not identified any drug-associated risks for major birth defects, miscarriages, or other adverse…
Brand names
United States
Cuvrior · Syprine
European Union
Cufence · Cuprior
Canada
Mar-Trientine · Waymade-Trientine
Other trade names
Metalite
Approval status
- US Food and Drug Administration
- prescription · since 1985
- European Medicines Agency
- authorised · since 2017
- Health Canada
- prescription · marketed
- First approval anywhere
- 1985
Codes
- ATC
- A16AX12
- RxNorm CUI
- 10798
- ChEMBL
- CHEMBL609
- PubChem CID
- 5565
- UNII
- SJ76Y07H5F
- Wikidata
- Q418386
Frequently asked questions
What is Trientine used for?
Trientine is used for: Wilson disease, Rheumatoid arthritis, and Primary biliary cholangitis.
What are the brand names of Trientine?
Brand names of Trientine include Cuvrior, Syprine, Cufence, Cuprior, Mar-Trientine, Waymade-Trientine, and Metalite.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)
- Health Canada Drug Product Database (Open Government Licence – Canada)