Sufentanil
Sufentanil is an approved active ingredient.
Chemical compound
Boxed warning (US label)
SERIOUS AND LIFE-THREATENING RISKS FROM USE OF SUFENTANIL CITRATE INJECTION Addiction, Abuse, and Misuse Because the use of Sufentanil Citrate Injection exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to…
What it is used for
- Pain
- Acute pain
- Postoperative pain
Sufentanil Citrate Injection is indicated for intravenous administration in adults and pediatric patients: • as an analgesic adjunct in the maintenance of balanced general anesthesia in patients who are intubated and ventilated. • as a primary anesthetic agent for the induction and maintenance of…
Dzuveo is indicated for the management of acute moderate to severe pain in adult patients.
How it works
- Mu opioid receptor agonist
Common side effects
The following serious adverse reactions are described, or described in greater detail, in other sections: • Addiction, Abuse, and Misuse • Life-Threatening Respiratory Depression • Skeletal Muscle Rigidity and Skeletal Muscle Movement • Interactions with Benzodiazepines or Other CNS Depressants • Severe…
Who should not take it
Sufentanil Citrate Injection is contraindicated in patients with: • Hypersensitivity to sufentanil (e.g., anaphylaxis) • Hypersensitivity to sufentanil.
Pregnancy and breastfeeding
Use of opioid analgesics for an extended period of time during pregnancy may cause neonatal opioid withdrawal syndrome.
Interactions
- Alprazolam — depressed level of consciousness, hypotension
- Aripiprazole — depressed level of consciousness, hypotension
- Baclofen — depressed level of consciousness, hypotension
- Chlordiazepoxide — hypotension, depressed level of consciousness
- Chlorphenamine — paralytic ileus
- Chlorpromazine — paralytic ileus, central respiratory depression, depressed level of consciousness
- Clarithromycin — central respiratory depression
- Clobazam — depressed level of consciousness, hypotension
- Clonazepam — depressed level of consciousness, hypotension
- Clozapine — central respiratory depression, depressed level of consciousness, paralytic ileus
- Codeine — depressed level of consciousness, central respiratory depression
- Crizotinib — sinus bradycardia, central respiratory depression
- Diazepam — hypotension, depressed level of consciousness
- Erythromycin — central respiratory depression
- Fentanyl — central respiratory depression, sinus bradycardia, depressed level of consciousness
- Haloperidol — hypotension, depressed level of consciousness
- Hydromorphone — depressed level of consciousness, central respiratory depression
- Hydroxyzine — depressed level of consciousness, paralytic ileus, central respiratory depression
- Lorazepam — depressed level of consciousness, hypotension
- Loxapine — depressed level of consciousness, central respiratory depression, paralytic ileus
- Methadone — depressed level of consciousness, sinus bradycardia, central respiratory depression
- Midazolam — depressed level of consciousness, hypotension
- Morphine — central respiratory depression, depressed level of consciousness
- Olanzapine — central respiratory depression, depressed level of consciousness, paralytic ileus
- Oxazepam — depressed level of consciousness, hypotension
- Oxycodone — central respiratory depression, depressed level of consciousness
- Pethidine — central respiratory depression, depressed level of consciousness
- Phenobarbital — central respiratory depression, depressed level of consciousness
- Posaconazole — central respiratory depression
- Promethazine — depressed level of consciousness, central respiratory depression, paralytic ileus
Brand names
United States
Dsuvia · Sufenta Preservative Free
European Union
Dzuveo
Other trade names
Sufental · Zalviso
Approval status
- US Food and Drug Administration
- prescription · since 1984
- European Medicines Agency
- authorised · since 2018
- Health Canada
- prescription · marketed
- First approval anywhere
- 1984
Codes
- ATC
- N01AH03
- RxNorm CUI
- 56795
- ChEMBL
- CHEMBL658
- PubChem CID
- 41693
- UNII
- AFE2YW0IIZ
- Wikidata
- Q417915
Frequently asked questions
What is Sufentanil used for?
Sufentanil is used for: Pain, Acute pain, and Postoperative pain.
What are the brand names of Sufentanil?
Brand names of Sufentanil include Dsuvia, Sufenta Preservative Free, Dzuveo, Sufental, and Zalviso.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)
- Health Canada Drug Product Database (Open Government Licence – Canada)