Silodosin
Silodosin is an approved active ingredient.
Chemical compound
What it is used for
- Prostatic hypertrophy
Silodosin, a selective alpha-1 adrenergic receptor antagonist, is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). Silodosin capsules are not indicated for the treatment of hypertension.
Treatment of the signs and symptoms of benign prostatic hyperplasia (BPH)
How it works
- Alpha-1a adrenergic receptor antagonist
Common side effects
Most common adverse reactions (incidence > 2%) are retrograde ejaculation, dizziness, diarrhea, orthostatic hypotension, headache, nasopharyngitis, and nasal congestion.
Who should not take it
Severe renal impairment (CCr < 30 mL/min) Severe hepatic impairment (Child-Pugh score ≥ 10) Concomitant administration with strong Cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ketoconazole, clarithromycin, itraconazole, ritonavir) Patients with a history…
Pregnancy and breastfeeding
Silodosin is not indicated for use in females.
and Males of Reproductive Potential Infertility Males Possible effects on male fertility could be observed based on findings in rats at exposures that were at least two times higher than at the MRHD (based on AUC).
Interactions
Brand names
United States
Rapaflo
European Union
Silodosin Recordati
Canada
Ag-Silodosin · Apo-Silodosin · Auro-Silodosin · Jamp Silodosin · Pms-Silodosin · Sandoz Silodosin
Approval status
- US Food and Drug Administration
- prescription · since 2008
- European Medicines Agency
- authorised · since 2010
- Health Canada
- prescription · marketed
- First approval anywhere
- 2008
Codes
- ATC
- G04CA04
- RxNorm CUI
- 720825
- ChEMBL
- CHEMBL24778
- PubChem CID
- 5312125
- UNII
- CUZ39LUY82
- Wikidata
- Q411770
Frequently asked questions
What is Silodosin used for?
Silodosin is used for: Prostatic hypertrophy.
What are the brand names of Silodosin?
Brand names of Silodosin include Rapaflo, Silodosin Recordati, Ag-Silodosin, Apo-Silodosin, Auro-Silodosin, Jamp Silodosin, Pms-Silodosin, and Sandoz Silodosin.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)
- Health Canada Drug Product Database (Open Government Licence – Canada)