Sevelamer
Sevelamer is an active ingredient of the class «antihyperkalemic agents».
Chemical compound
What it is used for
- Hyperphosphatemia
- Phosphorus metabolism disease
- Chronic renal insufficiency
- Renal dialysis
Renvela ® (sevelamer carbonate) is indicated for the control of serum phosphorus in adults and children 6 years of age and older with chronic kidney disease (CKD) on dialysis.
Sevelamer carbonate Winthrop is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.
How it works
- Unknown
Class: antihyperkalemic agents
Common side effects
In long-term studies with sevelamer hydrochloride, which contains the same active moiety as sevelamer carbonate, the most common adverse events included: vomiting (22%), nausea (20%), diarrhea (19%), dyspepsia (16%), abdominal pain (9%), flatulence (8%), and constipation (8%).
Who should not take it
Renvela is contraindicated in patients with bowel obstruction. Renvela is contraindicated in patients with known hypersensitivity to sevelamer carbonate, sevelamer hydrochloride, or to any of the excipients.
Pregnancy and breastfeeding
Sevelamer carbonate is not absorbed systemically following oral administration and maternal use is not expected to result in fetal exposure to the drug.
Interactions
Brand names
United States
Renvela
European Union
Renagel · Renvela · Sevelamer carbonate Winthrop (previously Sevelamer carbonate Zentiva)
Canada
Accel-Sevelamer · Renvela
Other trade names
Sevelamer carbonate zentiva
Approval status
- US Food and Drug Administration
- prescription · since 2007
- European Medicines Agency
- authorised · since 2000
- Health Canada
- prescription · marketed
- First approval anywhere
- 2007
Codes
- ATC
- V03AE02
- RxNorm CUI
- 214824
- ChEMBL
- CHEMBL5314349
- PubChem CID
- 3085017
- Wikidata
- Q904153
Frequently asked questions
What is Sevelamer used for?
Sevelamer is used for: Hyperphosphatemia, Phosphorus metabolism disease, Chronic renal insufficiency, and Renal dialysis.
What kind of medicine is Sevelamer?
Sevelamer is an active ingredient of the class «antihyperkalemic agents».
What are the brand names of Sevelamer?
Brand names of Sevelamer include Renvela, Renagel, Sevelamer carbonate Winthrop (previously Sevelamer carbonate Zentiva), Accel-Sevelamer, and Sevelamer carbonate zentiva.
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)
- Health Canada Drug Product Database (Open Government Licence – Canada)