Prochlorperazine
Prochlorperazine is an active ingredient of the class «antipsychotics».
Chemical compound
Boxed warning (US label)
WARNING Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
What it is used for
- Dementia
- Anxiety disorder
- Schizophreniform disorder
- Vomiting
- Postoperative nausea and vomiting
- Psychotic disorder
- Anxiety
- Schizophrenia
To control severe nausea and vomiting. For the treatment of schizophrenia. Prochlorperazine has not been shown effective in the management of behavioral complications in patients with mental retardation.
How it works
- Dopamine D2 receptor antagonist
Class: antipsychotics
Common side effects
Drowsiness, dizziness, amenorrhea, blurred vision, skin reactions and hypotension may occur. Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs.
Who should not take it
Do not use in patients with known hypersensitivity to phenothiazines. Do not use in comatose states or in the presence of large amounts of central nervous system depressants (alcohol, barbiturates, narcotics, etc.).
Pregnancy and breastfeeding
NON-TERATOGENIC EFFECTS Neonates exposed to antipsychotic drugs, during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery.
There is evidence that phenothiazines are excreted in the breast milk of nursing mothers. Caution should be exercised when prochlorperazine is administered to a nursing woman.
Interactions
Brand names
United States
Compazine
Canada
Odan-Prochlorperazine · Prochlorazine
Other trade names
Buccastem · Buccastem m · Compro · Procomp · Proziere · Stemetil eff · Vertigon
Approval status
- US Food and Drug Administration
- prescription · since 1956
- Health Canada
- prescription · marketed
- First approval anywhere
- 1956
Codes
- ATC
- N05AB04
- RxNorm CUI
- 8704
- ChEMBL
- CHEMBL728
- PubChem CID
- 4917
- UNII
- YHP6YLT61T
- Wikidata
- Q2359690
Frequently asked questions
What is Prochlorperazine used for?
Prochlorperazine is used for: Dementia, Anxiety disorder, Schizophreniform disorder, Vomiting, Postoperative nausea and vomiting, Psychotic disorder, Anxiety, and Schizophrenia.
What kind of medicine is Prochlorperazine?
Prochlorperazine is an active ingredient of the class «antipsychotics».
What are the brand names of Prochlorperazine?
Brand names of Prochlorperazine include Compazine, Odan-Prochlorperazine, Prochlorazine, Buccastem, Buccastem m, Compro, Procomp, and Proziere.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- Health Canada Drug Product Database (Open Government Licence – Canada)