Pentoxifylline
Pentoxifylline is an approved active ingredient.
Chemical compound
What it is used for
- Intermittent claudication
- Silent stroke
- Vasculitis
- Diabetic angiopathy
- Brain ischemia
- Diabetic polyneuropathy
- Cerebrovascular disease
- Cerebral malaria
- Peripheral vascular disease
- Vasculogenic impotence
- Arteriosclerosis
- Cardiovascular disease
TRENTAL is indicated for the treatment of patients with intermittent claudication on the basis of chronic occlusive arterial disease of the limbs.
How it works
- Adenosine A2 receptor antagonist
- 3',5'-cyclic phosphodiesterase inhibitor
Common side effects
Clinical trials were conducted using either extended-release TRENTAL tablets for up to 60 weeks or immediate-release TRENTAL capsules for up to 24 weeks. Dosage ranges in the tablet studies were 400 mg bid to tid and in the capsule studies, 200-400 mg tid.
Who should not take it
TRENTAL should not be used in patients with recent cerebral and/or retinal hemorrhage or in patients who have previously exhibited intolerance to this product or methylxanthines such as caffeine, theophylline, and theobromine.
Pregnancy and breastfeeding
Category C. Teratogenicity studies have been performed in rats and rabbits using oral doses up to 576 and 264 mg/kg, respectively.
Pentoxifylline and its metabolites are excreted in human milk.
Interactions
- Cimetidine
- Ciprofloxacin
- Fluvoxamine
- Insulin aspart
- Insulin degludec
- Insulin detemir
- Insulin glargine
- Insulin lispro
- Repaglinide
- Sodium citrate
Brand names
United States
Trental
Canada
Apo-Pentoxifylline · Jamp Pentoxifylline
Other trade names
Neotren mr · Pentoxil · Trental 100 · Trental 400
Approval status
- US Food and Drug Administration
- prescription · since 1984
- Health Canada
- prescription · marketed
- First approval anywhere
- 1984
Codes
- ATC
- C04AD03
- RxNorm CUI
- 8013
- ChEMBL
- CHEMBL628
- PubChem CID
- 4740
- UNII
- SD6QCT3TSU
- Wikidata
- Q416331
Frequently asked questions
What is Pentoxifylline used for?
Pentoxifylline is used for: Intermittent claudication, Silent stroke, Vasculitis, Diabetic angiopathy, Brain ischemia, Diabetic polyneuropathy, Cerebrovascular disease, and Cerebral malaria.
What are the brand names of Pentoxifylline?
Brand names of Pentoxifylline include Trental, Apo-Pentoxifylline, Jamp Pentoxifylline, Neotren mr, Pentoxil, Trental 100, and Trental 400.
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- Health Canada Drug Product Database (Open Government Licence – Canada)