AfoliOpen Afoli →

Oxymetazoline

Oxymetazoline is an active ingredient of the class «Topical decongestant».

Open in Afoli Medicines →

A topical decongestant

Informational only — not medical advice. Ask a doctor or pharmacist; never change a dose on your own.

What it is used for

UPNEEQ is indicated for the treatment of acquired blepharoptosis in adults. UPNEEQ is indicated for the treatment of acquired blepharoptosis in adults.

US label

How it works

Class: Topical decongestant

Common side effects

Most common adverse reactions (incidence 1-5%) are: punctate keratitis, conjunctival hyperemia, dry eye, vision blurred, instillation site pain, eye irritation and headache.

US label

Pregnancy and breastfeeding

There are no available data on UPNEEQ use in pregnant women to inform a drug-associated risk for major birth defects and miscarriage.

Excerpts from the US prescribing label (public domain), copied without changes.

Interactions

Recorded interactions from open sources (Wikidata, US labels). The list is not complete — ask a pharmacist.

Brand names

United States

Ocuclear · Rhofade · Upneeq · Visine L.r.

Canada

Aesb · Claritin Allergy Decongestant · Drixoral Decongestant Nasal Spray · Drixoral Nasal Congestion · Drixoral NO Drip Cooling Menthol · Drixoral NO Drip Extra Moisturizing · Drixoral NO Drip Nasal Congestion · Drixoral NO Drip Nasal Congestion With Menthol · Drixoral NO Drip Original Unscented · Extra Moisturizing Nasal Spray · Long Lasting Decongestant Nasal Spray · Long Lasting Dristan Mentholated Nasal Spray · Long Lasting Dristan Nasal Mist · Nasal Congestion Spray · Sbeb · Sinex Congestion Moisturizing · Sinex Congestion Ultra Fine Mist · Sinex Congestion Vapocool Ultra Fine Mist · Ydyb

Other trade names

Afrazine · Afrin

Approval status

US Food and Drug Administration
prescription and over-the-counter products · since 1986
Health Canada
over the counter · marketed
First approval anywhere
1986

Codes

ATC
D11AX27, R01AA05, R01AB07, S01GA04
RxNorm CUI
7812
ChEMBL
CHEMBL762
PubChem CID
4636
UNII
8VLN5B44ZY
Wikidata
Q417813

Frequently asked questions

What is Oxymetazoline used for?

Oxymetazoline is used for: Rosacea, Nasopharyngitis, Conjunctivitis, Rhinitis, Seasonal allergic rhinitis, Ocular changes, Nasal congestion, and Common cold.

What kind of medicine is Oxymetazoline?

Oxymetazoline is an active ingredient of the class «Topical decongestant».

What are the brand names of Oxymetazoline?

Brand names of Oxymetazoline include Ocuclear, Rhofade, Upneeq, Visine L.r., Aesb, Claritin Allergy Decongestant, Drixoral Decongestant Nasal Spray, and Drixoral Nasal Congestion.

Medicines in the same class

Sources and licences

Updated November 15, 2026