Nintedanib
Nintedanib is an approved active ingredient.
Chemical compound
What it is used for
- Interstitial lung disease
- Idiopathic lung fibrosis
- Systemic scleroderma
- Idiopathic pulmonary fibrosis
- Non-small-cell lung carcinoma
OFEV is a kinase inhibitor indicated in adults for: Treatment of idiopathic pulmonary fibrosis (IPF) Treatment of chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype Slowing the rate of decline in pulmonary function in patients with systemic sclerosis-associated…
Vargatef is indicated in combination with docetaxel for the treatment of adult patients with locally advanced, metastatic or locally recurrent non-small cell lung cancer (NSCLC) of adenocarcinoma tumour histology after first line chemotherapy.
How it works
- Platelet-derived growth factor receptor inhibitor
- Vascular endothelial growth factor receptor inhibitor
- Fibroblast growth factor receptor inhibitor
Common side effects
The following clinically significant adverse reactions are discussed in greater detail in other sections of the labeling: Elevated Liver Enzymes and Drug-Induced Liver Injury Gastrointestinal Disorders Embryo-Fetal Toxicity Arterial Thromboembolic Events Risk of Bleeding Gastrointestinal Perforation Nephrotic Range…
Pregnancy and breastfeeding
Based on findings from animal studies and its mechanism of action, OFEV can cause fetal harm when administered to a pregnant woman. There are no data on the use of OFEV during pregnancy.
Interactions
Brand names
United States
Ofev
European Union
Nintedanib Accord · Nintedanib Viatris · Ofev · Vargatef
Canada
Auro-Nintedanib · Eugia-Nintedanib · Gln-Nintedanib · Jamp Nintedanib · Ofev
Approval status
- US Food and Drug Administration
- prescription · since 2014
- European Medicines Agency
- authorised · since 2014
- Health Canada
- prescription · marketed
- First approval anywhere
- 2014
Codes
- ATC
- L01EX09
- RxNorm CUI
- 1592737
- ChEMBL
- CHEMBL502835
- PubChem CID
- 135423438
- UNII
- G6HRD2P839
- Wikidata
- Q15149723
Frequently asked questions
What is Nintedanib used for?
Nintedanib is used for: Interstitial lung disease, Idiopathic lung fibrosis, Systemic scleroderma, Idiopathic pulmonary fibrosis, and Non-small-cell lung carcinoma.
What are the brand names of Nintedanib?
Brand names of Nintedanib include Ofev, Nintedanib Accord, Nintedanib Viatris, Vargatef, Auro-Nintedanib, Eugia-Nintedanib, Gln-Nintedanib, and Jamp Nintedanib.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)
- Health Canada Drug Product Database (Open Government Licence – Canada)