Letrozole
Letrozole is an active ingredient of the class «aromatase inhibitors».
Chemical compound
What it is used for
- Low-grade serous carcinoma
- Breast cancer
- Invasive ductal carcinoma
- Breast neoplasm
- Neoplasm
Femara is an aromatase inhibitor indicated for: Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer. Extended adjuvant treatment of postmenopausal women with early breast cancer who have received prior standard adjuvant tamoxifen therapy.
How it works
- Cytochrome P450 19A1 inhibitor
Class: aromatase inhibitors
Common side effects
Bone effects Increases in cholesterol Fatigue and Dizziness The most common adverse reactions (greater than 20%) were hot flashes, arthralgia; flushing, asthenia, edema, arthralgia, headache, dizziness, hypercholesterolemia, sweating increased, bone pain; and musculoskeletal.
Who should not take it
: Letrozole can cause fetal harm. Known hypersensitivity to the active substance, or to any of the excipients. Pregnancy. Known hypersensitivity to the active substance, or to any of the excipients.
Pregnancy and breastfeeding
Based on postmarketing reports, findings from animal studies and the mechanism of action, Femara can cause fetal harm and is contraindicated for use in pregnant women.
Interactions
Brand names
Canada
Ach-Letrozole · Ag-Letrozole · Apo-Letrozole · Bio-Letrozole · Ipg-Letrozole · Jamp Letrozole · M-Letrozole · Mar-Letrozole · Mint-Letrozole · Nat-Letrozole · Nra-Letrozole · Pms-Letrozole · Riva-Letrozole · Sandoz Letrozole · Teva-Letrozole
Approval status
- US Food and Drug Administration
- prescription · since 1997
- Health Canada
- prescription · marketed
- First approval anywhere
- 1997
Codes
- ATC
- L02BG04
- RxNorm CUI
- 72965
- ChEMBL
- CHEMBL1444
- PubChem CID
- 3902
- UNII
- 7LKK855W8I
- Wikidata
- Q194974
Frequently asked questions
What is Letrozole used for?
Letrozole is used for: Low-grade serous carcinoma, Breast cancer, Invasive ductal carcinoma, Breast neoplasm, and Neoplasm.
What kind of medicine is Letrozole?
Letrozole is an active ingredient of the class «aromatase inhibitors».
What are the brand names of Letrozole?
Brand names of Letrozole include Ach-Letrozole, Ag-Letrozole, Apo-Letrozole, Bio-Letrozole, Ipg-Letrozole, Jamp Letrozole, M-Letrozole, and Mar-Letrozole.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- Health Canada Drug Product Database (Open Government Licence – Canada)