Isosorbide mononitrate
Isosorbide mononitrate is an active ingredient of the class «vasodilator agent».
Chemical compound
What it is used for
- Cardiovascular disease
- Coronary artery disease
- Angina pectoris
Isosorbide Mononitrate Tablets are indicated for the prevention and treatment of angina pectoris due to coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.
How it works
- Soluble guanylate cyclase activator
Class: vasodilator agent
Common side effects
Headache is the most frequent side effect and was the cause of 2% of all dropouts from controlled-clinical trials. Headache decreased in incidence after the first few days of therapy.
Who should not take it
Isosorbide mononitrate is contraindicated in patients who are allergic to it. Do not use isosorbide mononitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil.
Pregnancy and breastfeeding
Teratogenic Effects Pregnancy Category B Reproduction studies performed in rats and rabbits at doses of up to 540 and 810 mg/kg/day, respectively, have revealed no evidence of harm to the fetus due to isosorbide mononitrate.
It is not known whether isosorbide mononitrate is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when isosorbide mononitrate is administered to a nursing woman.
Brand names
United States
Imdur · Ismo · Monoket
Canada
Apo-Ismn · Pms-Ismn · Pro-Ismn · Prz-Ismn · Riva-Ismn
Other trade names
Angeze 10 · Angeze 20 · Angeze 40 · Angeze sr 40 · Angeze sr 60 · Angitate · Astrodur mr · Carmil xl · Chemydur 60 xl · Cibral 10 · Cibral 20 · Cibral 40 · Cibral xl 60 · Dynamin · Dynamin xl 25 · Dynamin xl 50 · Elantan 10 · Elantan 20 · Elantan 40 · Elantan la 25
Approval status
- US Food and Drug Administration
- prescription · since 1991
- Health Canada
- prescription · marketed
- First approval anywhere
- 1991
Codes
- ATC
- C01DA14
- RxNorm CUI
- 28004
- ChEMBL
- CHEMBL1311
- PubChem CID
- 27661
- UNII
- LX1OH63030
- Wikidata
- Q423401
Frequently asked questions
What is Isosorbide mononitrate used for?
Isosorbide mononitrate is used for: Cardiovascular disease, Coronary artery disease, and Angina pectoris.
What kind of medicine is Isosorbide mononitrate?
Isosorbide mononitrate is an active ingredient of the class «vasodilator agent».
What are the brand names of Isosorbide mononitrate?
Brand names of Isosorbide mononitrate include Imdur, Ismo, Monoket, Apo-Ismn, Pms-Ismn, Pro-Ismn, Prz-Ismn, and Riva-Ismn.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- Health Canada Drug Product Database (Open Government Licence – Canada)