Febuxostat
Febuxostat is an active ingredient of the class «antigout agent».
Chemical compound
Boxed warning (US label)
Cardiovascular death. Gout patients with established cardiovascular (CV) disease treated with ULORIC had a higher rate of CV death compared to those treated with allopurinol in a CV outcomes study.
What it is used for
- Hyperuricemia
- Gout
- Gouty arthritis
ULORIC is a xanthine oxidase (XO) inhibitor indicated for the chronic management of hyperuricemia in adult patients with gout who have an inadequate response to a maximally titrated dose of allopurinol, who are intolerant to allopurinol, or for whom treatment with allopurinol is not advisable.
Adenuric is indicated in adults. 120 mg strength: Adenuric is indicated for the treatment of chronic hyperuricaemia in conditions where urate deposition has already occurred (including a history, or presence of, tophus and/or gouty arthritis).
How it works
- Xanthine dehydrogenase inhibitor
Class: antigout agent
Common side effects
Most Common Adverse Reactions In three randomized, controlled clinical studies (Studies 1, 2 and 3), which were 6 to 12 months in duration, the following adverse reactions were reported by the treating physician as related to study drug.
Who should not take it
ULORIC is contraindicated in patients being treated with azathioprine or mercaptopurine. ULORIC is contraindicated in patients being treated with azathioprine or mercaptopurine.
Pregnancy and breastfeeding
Limited available data with ULORIC use in pregnant women are insufficient to inform a drug associated risk of adverse developmental outcomes.
Interactions
Brand names
United States
Uloric
European Union
Febuxostat Krka · Febuxostat Viatris (previously Febuxostat Mylan)
Canada
Auro-Febuxostat · Jamp Febuxostat · M-Febuxostat · Mar-Febuxostat · Teva-Febuxostat
Other trade names
Febuxostat mylan
Approval status
- US Food and Drug Administration
- prescription · since 2009
- European Medicines Agency
- authorised · since 2008
- Health Canada
- prescription · marketed
- First approval anywhere
- 2008
Codes
- ATC
- M04AA03
- RxNorm CUI
- 73689
- ChEMBL
- CHEMBL1164729
- PubChem CID
- 134018
- UNII
- 101V0R1N2E
- Wikidata
- Q417296
Frequently asked questions
What is Febuxostat used for?
Febuxostat is used for: Hyperuricemia, Gout, and Gouty arthritis.
What kind of medicine is Febuxostat?
Febuxostat is an active ingredient of the class «antigout agent».
What are the brand names of Febuxostat?
Brand names of Febuxostat include Uloric, Febuxostat Krka, Febuxostat Viatris (previously Febuxostat Mylan), Auro-Febuxostat, Jamp Febuxostat, M-Febuxostat, Mar-Febuxostat, and Teva-Febuxostat.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)
- Health Canada Drug Product Database (Open Government Licence – Canada)