Entacapone
Entacapone is an active ingredient of the class «dopaminergic».
One of the types of COMT inhibitors that is used for the treatment of Parkinson's disease
What it is used for
- Parkinson's disease
Entacapone Tablets are indicated as an adjunct to levodopa and carbidopa to treat end-of-dose “wearing-off” in patients with Parkinson’s disease.
Entacapone is indicated as an adjunct to standard preparations of levodopa / benserazide or levodopa / carbidopa for use in patients with Parkinson's disease and end-of-dose motor fluctuations, who cannot be stabilised on those combinations.
How it works
- Catechol O-methyltransferase inhibitor
Class: dopaminergic
Common side effects
The most commonly observed adverse reactions (incidence at least 3% greater than placebo) in double-blind, placebo-controlled studies (N=1,003) associated with the use of Entacapone Tablets were: dyskinesia, urine discoloration, diarrhea, nausea, hyperkinesia, abdominal pain, vomiting, and dry mouth.
Who should not take it
Entacapone Tablets are contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients.
Pregnancy and breastfeeding
Category C In embryofetal development studies, entacapone was administered to pregnant animals throughout organogenesis at doses of up to 1,000 mg/kg/day in rats and 300 mg/kg/day in rabbits.
Nursing Women In animal studies, entacapone was excreted into maternal rat milk. It is not known whether entacapone is excreted in human milk.
Interactions
- Methyldopa — tachycardia, hypertension, heart arrhythmia
- Warfarin
Brand names
United States
Comtan
European Union
Comtan · Comtess
Canada
Apo-Entacapone · Auro-Entacapone · Mint-Entacapone · Sandoz Entacapone · Teva-Entacapone
Approval status
- US Food and Drug Administration
- prescription · since 1999
- European Medicines Agency
- authorised · since 1998
- Health Canada
- prescription · marketed
- First approval anywhere
- 1998
Codes
- ATC
- N04BX02
- RxNorm CUI
- 60307
- ChEMBL
- CHEMBL953
- PubChem CID
- 5281081
- UNII
- 4975G9NM6T
- Wikidata
- Q416444
Frequently asked questions
What is Entacapone used for?
Entacapone is used for: Parkinson's disease.
What kind of medicine is Entacapone?
Entacapone is an active ingredient of the class «dopaminergic».
What are the brand names of Entacapone?
Brand names of Entacapone include Comtan, Comtess, Apo-Entacapone, Auro-Entacapone, Mint-Entacapone, Sandoz Entacapone, and Teva-Entacapone.
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)
- Health Canada Drug Product Database (Open Government Licence – Canada)