Cinacalcet
Cinacalcet is an approved active ingredient.
Chemical compound
What it is used for
- Secondary hyperparathyroidism
- Parathyroid gland disease
- Carcinoma
- Chronic renal insufficiency
- Parathyroid neoplasm
- Hyperparathyroidism
- Hypercalcemia
Sensipar is a positive modulator of the calcium sensing receptor indicated for: Secondary Hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on dialysis.
Parathyroid carcinoma and primary hyperparathyroidism in adults Reduction of hypercalcaemia in adult patients with: parathyroid carcinoma. primary HPT for whom parathyroidectomy would be indicated on the basis of serum calcium levels (as defined by relevant treatment…
How it works
- Calcium sensing receptor positive allosteric modulator
Common side effects
The following adverse reactions are discussed in greater detail in other sections of labeling: Hypocalcemia Upper Gastrointestinal Bleeding Hypotension, Worsening Heart Failure and/or Arrhythmias Adynamic Bone Disease The most common adverse reactions (i.e., ≥ 25%) associated with Sensipar were nausea and vomiting.
Who should not take it
Sensipar treatment initiation is contraindicated if serum calcium is less than the lower limit of the normal range. Sensipar treatment initiation is contraindicated if serum calcium is less than the lower limit of the normal range.
Pregnancy and breastfeeding
Limited case reports of Sensipar use in pregnant women are insufficient to inform a drug associated risk of adverse developmental outcomes.
Interactions
Brand names
United States
Sensipar
European Union
Cinacalcet Accordpharma · Cinacalcet Viatris (previously Cinacalcet Mylan)
Canada
Apo-Cinacalcet · Auro-Cinacalcet · Jamp Cinacalcet · M-Cinacalcet · Mar-Cinacalcet · Mylan-Cinacalcet · Reddy-Cinacalcet · Riva-Cinacalcet · Teva-Cinacalcet
Other trade names
Cinacalcet mylan · Mimpara · Parareg
Approval status
- US Food and Drug Administration
- prescription · since 2004
- European Medicines Agency
- authorised · since 2015
- Health Canada
- prescription · marketed
- First approval anywhere
- 2004
Codes
- ATC
- H05BX01
- RxNorm CUI
- 407990
- ChEMBL
- CHEMBL1201284
- PubChem CID
- 156419
- UNII
- UAZ6V7728S
- Wikidata
- Q193978
Frequently asked questions
What is Cinacalcet used for?
Cinacalcet is used for: Secondary hyperparathyroidism, Parathyroid gland disease, Carcinoma, Chronic renal insufficiency, Parathyroid neoplasm, Hyperparathyroidism, and Hypercalcemia.
What are the brand names of Cinacalcet?
Brand names of Cinacalcet include Sensipar, Cinacalcet Accordpharma, Cinacalcet Viatris (previously Cinacalcet Mylan), Apo-Cinacalcet, Auro-Cinacalcet, Jamp Cinacalcet, M-Cinacalcet, and Mar-Cinacalcet.
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)
- Health Canada Drug Product Database (Open Government Licence – Canada)