Chenodeoxycholic acid
Chenodeoxycholic acid is an approved active ingredient.
Chemical compound
What it is used for
- Cholestasis
- Cerebrotendinous xanthomatosis
- Inherited metabolic disorder
CTEXLI is indicated for the treatment of cerebrotendinous xanthomatosis (CTX) in adults. CTEXLI is a bile acid indicated for treatment of cerebrotendinous xanthomatosis (CTX) in adults.
Chenodeoxycholic acid is indicated for the treatment of inborn errors of primary bile acid synthesis due to sterol 27 hydroxylase deficiency (presenting as cerebrotendinous xanthomatosis (CTX)) in infants, children and adolescents aged 1 month to 18 years and adults.
How it works
- Bile acid receptor FXR agonist
Common side effects
The following clinically significant adverse reaction is described elsewhere in the labeling: • Hepatotoxicity The most common adverse reactions (incidence > 14%) are diarrhea, headache, abdominal pain, constipation, hypertension, muscular weakness, and upper respiratory tract infection.
Pregnancy and breastfeeding
Available data from published case reports over decades of use with chenodiol during pregnancy have not identified an increased risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes.
Brand names
United States
Chenix · Ctexli
European Union
Chenodeoxycholic acid Leadiant (previously Chenodeoxycholic acid sigma-tau)
Other trade names
Chendol 125 · Chendol 250 · Chenocedon · Chenodeoxycholic acid leadiant (previously known as chenodeoxycholic acid sigma-tau) · Chenofalk · Combidol · Lithofalk · Xenbilox
Approval status
- US Food and Drug Administration
- prescription · since 1983
- European Medicines Agency
- authorised · since 2017
- First approval anywhere
- 1983
Codes
- ATC
- A05AA01
- RxNorm CUI
- 2323
- ChEMBL
- CHEMBL240597
- PubChem CID
- 10133
- UNII
- 0GEI24LG0J
- Wikidata
- Q419028
Frequently asked questions
What is Chenodeoxycholic acid used for?
Chenodeoxycholic acid is used for: Cholestasis, Cerebrotendinous xanthomatosis, and Inherited metabolic disorder.
What are the brand names of Chenodeoxycholic acid?
Brand names of Chenodeoxycholic acid include Chenix, Ctexli, Chenodeoxycholic acid Leadiant (previously Chenodeoxycholic acid sigma-tau), Chendol 125, Chendol 250, Chenocedon, Chenodeoxycholic acid leadiant (previously known as chenodeoxycholic acid sigma-tau), and Chenofalk.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)