Anagrelide
Anagrelide is an approved active ingredient.
Chemical compound
What it is used for
- Polycythemia vera
- Thrombocytopenia
- Myeloproliferative disorders
- Thrombogavitis
- Essential thrombocytosis
- Thrombosis
- Neoplasm
AGRYLIN is indicated for the treatment of patients with thrombocythemia, secondary to myeloproliferative neoplasms, to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms including thrombo-hemorrhagic events.
Xagrid is indicated for the reduction of elevated platelet counts in at-risk essential-thrombocythaemia (ET) patients who are intolerant to their current therapy or whose elevated platelet counts are not reduced to an acceptable level by their current therapy.
How it works
- Phosphodiesterase 3 inhibitor
Common side effects
The following clinically significant adverse reactions are discussed in greater detail in other sections of the labeling: Cardiovascular Toxicity Pulmonary Hypertension Bleeding Risk Pulmonary Toxicity The most common adverse reactions (incidence ≥ 5%) are headache, palpitations, diarrhea, asthenia, edema, nausea…
Pregnancy and breastfeeding
Available data from case reports with AGRYLIN use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.
Interactions
- Amiodarone — long QT syndrome, torsades de pointes
- Arsenic trioxide — long QT syndrome
- Aspirin — retroperitoneal hemorrhage
- Chlorpromazine — long QT syndrome
- Citalopram — long QT syndrome, retroperitoneal hemorrhage
- Clopidogrel — retroperitoneal hemorrhage
- Crizotinib — long QT syndrome
- Domperidone — long QT syndrome
- Erythromycin — long QT syndrome
- Haloperidol — long QT syndrome
- Hydroxyzine — long QT syndrome
- Methadone — long QT syndrome
- Moxifloxacin — long QT syndrome
- Pentamidine — long QT syndrome
- Sotalol — long QT syndrome
- Ticagrelor — retroperitoneal hemorrhage
- Azithromycin
- Chloroquine
- Ciprofloxacin
- Clarithromycin
- Escitalopram
- Fluvoxamine
- Omeprazole
- Ondansetron
- Procainamide
- Quinidine
Brand names
European Union
Anagrelide Viatris (previously Anagrelide Mylan) · Xagrid
Canada
Pms-Anagrelide
Other trade names
Agrelin · Anagrelide mylan
Approval status
- US Food and Drug Administration
- prescription · since 1997
- European Medicines Agency
- authorised · since 2004
- Health Canada
- prescription · marketed
- First approval anywhere
- 1997
Codes
- ATC
- L01XX35
- RxNorm CUI
- 596724
- ChEMBL
- CHEMBL760
- PubChem CID
- 135409400
- UNII
- K9X45X0051
- Wikidata
- Q408163
Frequently asked questions
What is Anagrelide used for?
Anagrelide is used for: Polycythemia vera, Thrombocytopenia, Myeloproliferative disorders, Thrombogavitis, Essential thrombocytosis, Thrombosis, and Neoplasm.
What are the brand names of Anagrelide?
Brand names of Anagrelide include Anagrelide Viatris (previously Anagrelide Mylan), Xagrid, Pms-Anagrelide, Agrelin, and Anagrelide mylan.
Medicines in the same class
- Arsenic trioxide
- Celecoxib
- Tretinoin
- Hydroxycarbamide
- Irinotecan
- Bortezomib
- Miltefosine
- Pegaspargase
- Aflibercept
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- European Medicines Agency (reuse with acknowledgement)
- Health Canada Drug Product Database (Open Government Licence – Canada)