Alprostadil
Alprostadil is an active ingredient of the class «prostaglandins».
Chemical compound
Boxed warning (US label)
WARNING Apnea is experienced by about 10 to 12% of neonates with congenital heart defects treated with PROSTIN VR PEDIATRIC Sterile Solution.
What it is used for
- Tetralogy of Fallot
- Pulmonary hypertension
- Tricuspid atresia
- Hypoplastic left heart syndrome
- Vasculogenic impotence
- Patent ductus arteriosus
- Takayasu's arteritis
- Pulmonary valve stenosis
- Coarctation of the aorta
- Congenital heart disease
- Erectile dysfunction
- Cardiovascular disease
PROSTIN VR PEDIATRIC Sterile Solution is indicated for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for…
How it works
- Prostanoid EP1 receptor agonist
- Prostanoid EP2 receptor agonist
Class: prostaglandins
Common side effects
Cardiovascular System The most common adverse reactions reported have been flushing in about 10% of patients (more common after intraarterial dosing), bradycardia in about 7%, hypotension in about 4%, tachycardia in about 3%, cardiac arrest in about 1%, and edema in about 1%.
Interactions
Brand names
United States
Caverject · Caverject Impulse · Edex · Muse · Prostin VR Pediatric
Canada
Caverject Sterile Powder · Prostin VR Sterile · Vitaros
Other trade names
Prostin vr · Viridal 10 · Viridal 20 · Viridal 5 · Viridal duo
Approval status
- US Food and Drug Administration
- prescription · since 1981
- Health Canada
- prescription · marketed
- First approval anywhere
- 1981
Codes
- ATC
- C01EA01, G04BE01
- RxNorm CUI
- 598
- ChEMBL
- CHEMBL495
- PubChem CID
- 5280723
- UNII
- F5TD010360
- Wikidata
- Q579348
Frequently asked questions
What is Alprostadil used for?
Alprostadil is used for: Tetralogy of Fallot, Pulmonary hypertension, Tricuspid atresia, Hypoplastic left heart syndrome, Vasculogenic impotence, Patent ductus arteriosus, Takayasu's arteritis, and Pulmonary valve stenosis.
What kind of medicine is Alprostadil?
Alprostadil is an active ingredient of the class «prostaglandins».
What are the brand names of Alprostadil?
Brand names of Alprostadil include Caverject, Caverject Impulse, Edex, Muse, Prostin VR Pediatric, Caverject Sterile Powder, Prostin VR Sterile, and Vitaros.
Medicines in the same class
Sources and licences
- ChEMBL (CC BY-SA 3.0)
- Wikidata (CC0 1.0)
- openFDA / DailyMed (public domain)
- Health Canada Drug Product Database (Open Government Licence – Canada)